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Identifying Ligand Binding Conformations of the β2-Adrenergic Receptor by Using Its Agonists as Computational Probes

Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational ensembles of the proteins need to be consider...

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Bibliografski detalji
Glavni autori: Isin, Basak, Estiu, Guillermina, Wiest, Olaf, Oltvai, Zoltán N.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534076/
https://ncbi.nlm.nih.gov/pubmed/23300522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050186
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