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Identifying Ligand Binding Conformations of the β2-Adrenergic Receptor by Using Its Agonists as Computational Probes

Recently available G-protein coupled receptor (GPCR) structures and biophysical studies suggest that the difference between the effects of various agonists and antagonists cannot be explained by single structures alone, but rather that the conformational ensembles of the proteins need to be consider...

詳細記述

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書誌詳細
主要な著者: Isin, Basak, Estiu, Guillermina, Wiest, Olaf, Oltvai, Zoltán N.
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3534076/
https://ncbi.nlm.nih.gov/pubmed/23300522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0050186
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