Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response

In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion of reactive oxygen species (ROS) and bioactive peptides including pro-inflammatory cytokines. This makes senescent cells a potential cause of tissue functional declin...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Jurk, Diana, Wang, Chunfang, Miwa, Satomi, Maddick, Mandy, Korolchuk, Viktor, Tsolou, Avgi, Gonos, Efstathios S, Thrasivoulou, Christopher, Jill Saffrey, M, Cameron, Kerry, von Zglinicki, Thomas
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Blackwell Publishing Ltd 2012
विषय:
Original Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533793/
https://ncbi.nlm.nih.gov/pubmed/22882466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2012.00870.x
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