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The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation

The mitotic checkpoint plays an important role in preventing chromosome segregation errors and the production of aneuploid progeny. In this issue, Zhang et al. examine mice and cells lacking the deubiquitinating enzyme USP44. Surprisingly, they find that USP44 prevents chromosome segregation errors...

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Detalles Bibliográficos
Autores principales: Holland, Andrew J., Cleveland, Don W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2012
Materias:
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533566/
https://ncbi.nlm.nih.gov/pubmed/23187131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66420
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