ER stress–mediated autophagy promotes Myc-dependent transformation and tumor growth

The proto-oncogene c-Myc paradoxically activates both proliferation and apoptosis. In the pathogenic state, c-Myc–induced apoptosis is bypassed via a critical, yet poorly understood escape mechanism that promotes cellular transformation and tumorigenesis. The accumulation of unfolded proteins in the...

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Detalhes bibliográficos
Main Authors: Hart, Lori S., Cunningham, John T., Datta, Tatini, Dey, Souvik, Tameire, Feven, Lehman, Stacey L., Qiu, Bo, Zhang, Haiyan, Cerniglia, George, Bi, Meixia, Li, Yan, Gao, Yan, Liu, Huayi, Li, Changhong, Maity, Amit, Thomas-Tikhonenko, Andrei, Perl, Alexander E., Koong, Albert, Fuchs, Serge Y., Diehl, J. Alan, Mills, Ian G., Ruggero, Davide, Koumenis, Constantinos
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533536/
https://ncbi.nlm.nih.gov/pubmed/23143306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI62973
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