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Extracellular Loop II Modulates GTP Sensitivity of the Prostaglandin EP3 Receptor
Unlike the majority of G protein–coupled receptors, the prostaglandin E(2) (PGE(2)) E-prostanoid 3 (EP3) receptor binds agonist with high affinity that is insensitive to the presence of guanosine 5[prime]-O-(3-thio)triphosphate (GTPγS). We report the identification of mutations that confer GTPγS sen...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
The American Society for Pharmacology and Experimental Therapeutics
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3533480/ https://ncbi.nlm.nih.gov/pubmed/23087260 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.112.080473 |
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