Differential Influences of Ethanol on Early Exposure to Racemic Methylphenidate Compared with Dexmethylphenidate in Humans

Enantioselective hydrolysis of oral racemic methylphenidate (dl-MPH) by carboxylesterase 1 (CES1) limits the absolute bioavailability of the pharmacologically active d-MPH isomer to approximately 30% and that of the inactive l-MPH to only 1–2%. Coadministration of dl-MPH with ethanol results in elev...

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Main Authors: Patrick, Kennerly S., Straughn, Arthur B., Reeves, Owen T., Bernstein, Hilary, Bell, Guinevere H., Anderson, Erica R., Malcolm, Robert J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533423/
https://ncbi.nlm.nih.gov/pubmed/23104969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.048595
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