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Transdermal and Oral dl-Methylphenidate–Ethanol Interactions in C57BL/6J Mice: Transesterification to Ethylphenidate and Elevation of d-Methylphenidate Concentrations

We tested the hypothesis that C57BL/6J mice will model human metabolic interactions between dl-methylphenidate (MPH) and ethanol, placing an emphasis on the MPH transdermal system (MTS). Specifically, we asked: (1) will ethanol increase d-MPH biological concentrations, (2) will MTS facilitate the sy...

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Dettagli Bibliografici
Pubblicato in:J Pharm Sci
Autori principali: BELL, GUINEVERE H., NOVAK, ANDREW J., GRIFFIN, WILLIAM C., PATRICK, KENNERLY S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4429779/
https://ncbi.nlm.nih.gov/pubmed/21240977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22476
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