Efficacy of the GluK1/AMPA Receptor Antagonist LY293558 against Seizures and Neuropathology in a Soman-Exposure Model without Pretreatment and its Pharmacokinetics after Intramuscular Administration

Control of brain seizures after exposure to nerve agents is imperative for the prevention of brain damage and death. Animal models of nerve agent exposure make use of pretreatments, or medication administered within 1 minute after exposure, in order to prevent rapid death from peripheral toxic effec...

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Main Authors: Apland, James P., Aroniadou-Anderjaska, Vassiliki, Figueiredo, Taiza H., Green, Carol E., Swezey, Robert, Yang, Chun, Qashu, Felicia, Braga, Maria F. M.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533413/
https://ncbi.nlm.nih.gov/pubmed/23042954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.112.198689
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