Heterodimerization with the Prostacyclin Receptor Triggers Thromboxane Receptor Relocation to Lipid Rafts

OBJECTIVE: Prostacyclin and thromboxane mediate opposing cardiovascular actions through receptors termed IP and TP, respectively. When dimerized with IP, the TP shifts to IP-like function. IP localizes to cholesterol-enriched membrane rafts but TP and IPTP heterodimer localization is not defined. We...

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Bibliographic Details
Main Authors: Ibrahim, Salam, McCartney, Ann, Markosyan, Nune, Smyth, Emer M
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533363/
https://ncbi.nlm.nih.gov/pubmed/23162015
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.112.300536
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