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Heterodimerization of the α and β isoforms of the human Thromboxane receptor enhances isoprostane signalling.
Isoprostanes are free radical catalyzed products of arachidonic acid that are elevated in pro-oxidant disease states. Two isoprostanes, 8-isoprostaglandin F(2α) (iPF(2α)III) and 8-isoprostaglandin E(2) (iPE(2)III) act at the receptor for thromboxane A(2) (the TP) to mediate pro-atherogenic effects i...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1766557/ https://ncbi.nlm.nih.gov/pubmed/17134677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.11.040 |
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