Heterodimerization of the α and β isoforms of the human Thromboxane receptor enhances isoprostane signalling.

Isoprostanes are free radical catalyzed products of arachidonic acid that are elevated in pro-oxidant disease states. Two isoprostanes, 8-isoprostaglandin F(2α) (iPF(2α)III) and 8-isoprostaglandin E(2) (iPE(2)III) act at the receptor for thromboxane A(2) (the TP) to mediate pro-atherogenic effects i...

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Hlavní autoři: Wilson, Stephen J., McGinley, Kevin, Huang, Albert J., Smyth., Emer M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1766557/
https://ncbi.nlm.nih.gov/pubmed/17134677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2006.11.040
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