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Differential regulation of RhoA-mediated signaling by the TPα and TPβ isoforms of the human thromboxane A2 receptor: Independent modulation of TPα signaling by prostacyclin and nitric oxide

In humans, thromboxane (TX) A(2) signals through the TPα and TPβ isoforms of the TXA(2) receptor that exhibit common and distinct roles. For example, Gq/phospholipase (PL)Cβ signaling by TPα is directly inhibited by the vasodilators prostacyclin and nitric oxide (NO) whereas that signaling by TPβ is...

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Bibliografski detalji
Glavni autori: Wikström, Katarina, Kavanagh, David J., Reid, Helen M., Kinsella, B. Therese
Format: Artigo
Jezik:Inglês
Izdano: Elsevier Science Ltd 2008
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2681257/
https://ncbi.nlm.nih.gov/pubmed/18502100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2008.04.006
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