Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk

Neurofibromatosis type 1 (NF1) predisposes individuals to the development of juvenile myelomonocytic leukemia (JMML), a fatal myeloproliferative disease (MPD). In genetically engineered murine models, nullizygosity of Nf1, a tumor suppressor gene that encodes a Ras-GTPase–activating protein, results...

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Detalhes bibliográficos
Main Authors: Staser, Karl, Park, Su-Jung, Rhodes, Steven D., Zeng, Yi, He, Yong Zheng, Shew, Matthew A., Gehlhausen, Jeffrey R., Cerabona, Donna, Menon, Keshav, Chen, Shi, Sun, Zejin, Yuan, Jin, Ingram, David A., Nalepa, Grzegorz, Yang, Feng-Chun, Clapp, D. Wade
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2012
Assuntos:
Brief Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533306/
https://ncbi.nlm.nih.gov/pubmed/23221339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI66167
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