CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPARγ signaling

Aberrant expression of the homeodomain transcription factor CDX2 occurs in most cases of acute myeloid leukemia (AML) and promotes leukemogenesis, making CDX2, in principle, an attractive therapeutic target. Conversely, CDX2 acts as a tumor suppressor in colonic epithelium. The effectors mediating t...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Faber, Katrin, Bullinger, Lars, Ragu, Christine, Garding, Angela, Mertens, Daniel, Miller, Christina, Martin, Daniela, Walcher, Daniel, Döhner, Konstanze, Döhner, Hartmut, Claus, Rainer, Plass, Christoph, Sykes, Stephen M., Lane, Steven W., Scholl, Claudia, Fröhling, Stefan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Clinical Investigation 2012
Θέματα:
Research Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533294/
https://ncbi.nlm.nih.gov/pubmed/23202735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64745
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