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Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs

TLR activation on CD11c(+) DCs triggers DC maturation, which is critical for T cell activation. Given the expansion of CD11c(+) DCs during the progression of atherosclerosis and the key role of T cell activation in atherogenesis, we sought to understand the role of TLR signaling in CD11c(+) DCs in a...

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Bibliografische gegevens
Hoofdauteurs: Subramanian, Manikandan, Thorp, Edward, Hansson, Goran K., Tabas, Ira
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533292/
https://ncbi.nlm.nih.gov/pubmed/23257360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI64617
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