Downregulation of KLF6 is an early event in hepatocarcinogenesis, and stimulates proliferation while reducing differentiation

BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) has the most rapidly rising cancer incidence in the US and Europe. The KLF6 tumor suppressor is frequently inactivated in HCC by loss-of-heterozygosity (LOH) and/or mutation. METHODS: Here we have analyzed 33 HBV- and 40 HCV-related HCCs for mRNA expre...

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Autors principals: Kremer-Tal, Sigal, Narla, Goutham, Chen, Yingbei, Hod, Eldad, DiFeo, Analisa, Yea, Steven, Lee, Ju-Seog, Schwartz, Myron, Thung, Swan N., Fiel, Isabel M., Banck, Michaela, Zimran, Eran, Thorgeirsson, Snorri S., Mazzaferro, Vincenzo, Bruix, Jordi, Martignetti, John A., Llovet, Josep M., Friedman, Scott L.
Format: Artigo
Idioma:Inglês
Publicat: 2006
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533246/
https://ncbi.nlm.nih.gov/pubmed/17196295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jhep.2006.10.012
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