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Spatial gradients in action potential duration created by regional magnetofection of hERG are a substrate for wavebreak and turbulent propagation in cardiomyocyte monolayers

Spatial dispersion of action potential duration (APD) is a substrate for the maintenance of cardiac fibrillation, but the mechanisms are poorly understood. We investigated the role played by spatial APD dispersion in fibrillatory dynamics. We used an in vitro model in which spatial gradients in the...

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Hlavní autoři: Campbell, Katherine, Calvo, Conrado J, Mironov, Sergey, Herron, Todd, Berenfeld, Omer, Jalife, José
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2012
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533198/
https://ncbi.nlm.nih.gov/pubmed/23090949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.238758
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