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Spatial gradients in action potential duration created by regional magnetofection of hERG are a substrate for wavebreak and turbulent propagation in cardiomyocyte monolayers

Spatial dispersion of action potential duration (APD) is a substrate for the maintenance of cardiac fibrillation, but the mechanisms are poorly understood. We investigated the role played by spatial APD dispersion in fibrillatory dynamics. We used an in vitro model in which spatial gradients in the...

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Detalhes bibliográficos
Main Authors: Campbell, Katherine, Calvo, Conrado J, Mironov, Sergey, Herron, Todd, Berenfeld, Omer, Jalife, José
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3533198/
https://ncbi.nlm.nih.gov/pubmed/23090949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2012.238758
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