Structural heterogeneity promotes triggered activity, reflection and arrhythmogenesis in cardiomyocyte monolayers

ABSTRACT: Patients with structural heart disease are predisposed to arrhythmias by incompletely understood mechanisms. We hypothesized that tissue expansions promote source-to-sink mismatch leading to early after-depolarizations (EADs) and reflection of impulses in monolayers of well-polarized neona...

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Главные авторы: Auerbach, David S, Grzȩda, Krzysztof R, Furspan, Philip B, Sato, Priscila Y, Mironov, Sergey, Jalife, José
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Science Inc 2011
Предметы:
Cardiovascular
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3098708/
https://ncbi.nlm.nih.gov/pubmed/21486795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2010.200576
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