Greater insulin-mediated Akt phosphorylation concomitant with heterogeneous effects on phosphorylation of Akt substrates in soleus of calorie-restricted rats

Akt is a serine/threonine kinase that plays a key role in numerous cellular functions including metabolism, growth, protein synthesis, apoptosis, and cell proliferation. The most consistent and robust effect of moderate calorie restriction (CR; ∼60% of ad libitum, AL, food consumption) on insulin si...

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Main Authors: Sharma, Naveen, Sequea, Donel A., Arias, Edward B., Cartee, Gregory D.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2012
Assuntos:
Obesity, Diabetes and Energy Homeostasis
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532588/
https://ncbi.nlm.nih.gov/pubmed/23115120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpregu.00457.2012
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