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Local delivery of gene-modifying triplex-forming molecules to epidermis
Epidermal keratinocytes are particularly suitable candidates for in situ gene correction. Intraperitoneal administration of a triplex-forming oligonucleotide (TFO) was shown previously to introduce DNA base changes in a reporter gene in skin, without identifying which cells had been targeted. We ext...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532560/ https://ncbi.nlm.nih.gov/pubmed/23014335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.351 |
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