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Local delivery of gene-modifying triplex-forming molecules to epidermis

Epidermal keratinocytes are particularly suitable candidates for in situ gene correction. Intraperitoneal administration of a triplex-forming oligonucleotide (TFO) was shown previously to introduce DNA base changes in a reporter gene in skin, without identifying which cells had been targeted. We ext...

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Detalhes bibliográficos
Main Authors: Rogers, Faye A., Hu, Rong-Hua, Milstone, Leonard M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532560/
https://ncbi.nlm.nih.gov/pubmed/23014335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jid.2012.351
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