Melatonin inhibits nitric oxide signaling by increasing PDE5 phosphorylation in coronary arteries

Melatonin inhibits nitric oxide (NO)-induced relaxation of coronary arteries. We tested the hypothesis that melatonin increases the phosphorylation of phosphodiesterase 5 (PDE5), which increases the activity of the enzyme and thereby decreases intracellular cGMP accumulation in response to NO and in...

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Bibliographic Details
Main Authors: Shukla, Praveen, Sun, Chengwen, O'Rourke, Stephen T.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2012
Subjects:
Cardiovascular Neurohormonal Regulation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532536/
https://ncbi.nlm.nih.gov/pubmed/23086989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00211.2012
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