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Melatonin inhibits nitric oxide signaling by increasing PDE5 phosphorylation in coronary arteries
Melatonin inhibits nitric oxide (NO)-induced relaxation of coronary arteries. We tested the hypothesis that melatonin increases the phosphorylation of phosphodiesterase 5 (PDE5), which increases the activity of the enzyme and thereby decreases intracellular cGMP accumulation in response to NO and in...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532536/ https://ncbi.nlm.nih.gov/pubmed/23086989 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00211.2012 |
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