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Structural basis for DNA-dependent poly(ADP-ribosyl)ation by human PARP-1
Poly(ADP-ribose) polymerase-1 (PARP-1) has a modular domain architecture that couples DNA damage detection to poly(ADP-ribosyl)ation activity through a poorly understood mechanism. Here we report the crystal structure of a DNA double-strand break in complex with human PARP-1 domains essential for ac...
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| 主要な著者: | , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3532513/ https://ncbi.nlm.nih.gov/pubmed/22582261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1216338 |
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