Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney

Candidate genes have been identified that confer increased risk for diabetic glomerulosclerosis (DG). Mice heterozygous for the Akita (Ins2(+/C96Y)) diabetogenic mutation with a second mutation introduced at the bradykinin 2 receptor (B2R(−/−)) locus express a disease phenotype that approximates hum...

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Autors principals: Vashistha, Himanshu, Singhal, Pravin C., Malhotra, Ashwani, Husain, Mohammad, Mathieson, Peter, Saleem, Moin A., Kuriakose, Cyril, Seshan, Surya, Wilk, Anna, DelValle, Luis, Peruzzi, Francesca, Giorgio, Marco, Pelicci, Pier Giuseppe, Smithies, Oliver, Kim, Hyung-Suk, Kakoki, Masao, Reiss, Krzysztof, Meggs, Leonard G.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2012
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532473/
https://ncbi.nlm.nih.gov/pubmed/23019230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00246.2012
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