The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1

Progranulin (PGRN), a secreted growth factor, regulates the proliferation of various epithelial cells. Its mechanism of action is largely unknown. Sirtuin 1 (Sirt1) is a protein deacetylase that is known to regulate the transcriptional activity of the forkhead receptor FOXO1, thereby modulating the...

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Hlavní autoři: Frampton, Gabriel, Ueno, Yoshiyuki, Quinn, Matthew, McMillin, Matthew, Pae, Hae Yong, Galindo, Cheryl, Leyva-Illades, Dinorah, DeMorrow, Sharon
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2012
Témata:
Liver and Biliary Tract
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3532458/
https://ncbi.nlm.nih.gov/pubmed/23086914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00104.2012
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