Lipid Raft-dependent Endocytosis of Close Homolog of Adhesion Molecule L1 (CHL1) Promotes Neuritogenesis

CHL1 plays a dual role by either promoting or inhibiting neuritogenesis. We report here that neuritogenesis-promoting ligand-dependent cell surface clustering of CHL1 induces palmitoylation and lipid raft-dependent endocytosis of CHL1. We identify βII spectrin as a binding partner of CHL1, and we sh...

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Autores principales: Tian, Nan, Leshchyns'ka, Iryna, Welch, Jeffrey H., Diakowski, Witold, Yang, Hongyuan, Schachner, Melitta, Sytnyk, Vladimir
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Neurobiology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531758/
https://ncbi.nlm.nih.gov/pubmed/23144456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.394973
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