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Carabin deficiency in B cells increases BCR-TLR9 costimulation-induced autoimmunity

The mechanisms behind flares of human autoimmune diseases in general, and of systemic lupus in particular, are poorly understood. The present scenario proposes that predisposing gene defects favour clinical flares under the influence of external stimuli. Here, we show that Carabin is low in B cells...

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Autors principals: Schickel, Jean-Nicolas, Pasquali, Jean-Louis, Soley, Anne, Knapp, Anne-Marie, Decossas, Marion, Kern, Aurélie, Fauny, Jean-Daniel, Marcellin, Luc, Korganow, Anne-Sophie, Martin, Thierry, Soulas-Sprauel, Pauline
Format: Artigo
Idioma:Inglês
Publicat: WILEY-VCH Verlag 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531602/
https://ncbi.nlm.nih.gov/pubmed/23109291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201201595
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