Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation, Anti-Pluripotency and DNA Demethylation

Human embryonal carcinoma (EC) cells are the stem cells of nonseminoma testicular germ cells tumors (TGCTs) and share remarkable similarities to human embryonic stem (ES) cells. In prior work we found that EC cells are hypersensitive to low nanomolar doses of 5-aza deoxycytidine (5-aza) and that thi...

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Hauptverfasser: Biswal, Bijesh K., Beyrouthy, Maroun J., Hever-Jardine, Mary P., Armstrong, David, Tomlinson, Craig R., Christensen, Brock C., Marsit, Carmen J., Spinella, Michael J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2012
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3531428/
https://ncbi.nlm.nih.gov/pubmed/23300844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0053003
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