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Preclinical Pharmacology and Pharmacokinetics of GW433908, a Water-Soluble Prodrug of the Human Immunodeficiency Virus Protease Inhibitor Amprenavir

GW433908 is the water-soluble, phosphate ester prodrug of the human immunodeficiency virus type 1 protease inhibitor amprenavir (APV). A high-yield synthesis of GW433908 is achieved by phosphorylation of the penultimate precursor of APV with phosphorous oxychloride (POCl(3)) in pyridine. A single-do...

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Autors principals: Furfine, Eric S., Baker, Christopher T., Hale, Michael R., Reynolds, David J., Salisbury, Jo A., Searle, Andy D., Studenberg, Scott D., Todd, Dan, Tung, Roger D., Spaltenstein, Andrew
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC353103/
https://ncbi.nlm.nih.gov/pubmed/14982766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.3.791-798.2004
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