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Structural homology modeling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel
The Na(V)1.7 voltage-gated sodium channel is critical for pain signaling in humans. Gain-of-function mutations are associated with several pain syndromes including inherited erythromelalgia (IEM). Most IEM patients with Na(V)1.7 mutations are resistant to pharmacotherapy, but carbamazepine (CBZ) nor...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3530897/ https://ncbi.nlm.nih.gov/pubmed/23149731 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms2184 |
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