A common SNP in ER aminopeptidase 2 induces a specificity switch that leads to altered antigen processing

ER aminopeptidases 1 and 2 (ERAP1 and ERAP2) cooperate to trim antigenic peptide precursors for loading onto MHC class I molecules and help regulate the adaptive immune response. Common coding single nucleotide polymorphisms (SNPs) in ERAP1 and ERAP2 have been linked with predisposition to human dis...

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Main Authors: Evnouchidou, Irini, Birtley, James, Seregin, Sergey, Papakyriakou, Athanasios, Zervoudi, Efthalia, Samiotaki, Martina, Panayotou, George, Giastas, Petros, Petrakis, Olivia, Georgiadis, Dimitris, Amalfitano, Andrea, Saridakis, Emmanuel, Mavridis, Irene M., Stratikos, Efstratios
Format: Artigo
Language:Inglês
Published: 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530405/
https://ncbi.nlm.nih.gov/pubmed/22837489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1200918
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