Melanoma whole exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

The development of acquired drug resistance hampers the long-term success of B-RAF inhibitor (B-RAFi) therapy for melanoma patients. Here we show (V600E)B-RAF copy number gain as a mechanism of acquired B-RAFi resistance in four out of twenty (20%) patients treated with B-RAFi. In cell lines, (V600E...

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Bibliografiske detaljer
Main Authors: Shi, Hubing, Moriceau, Gatien, Kong, Xiangju, Lee, Mi-Kyung, Lee, Hane, Koya, Richard C., Ng, Charles, Chodon, Thinle, Scolyer, Richard A., Dahlman, Kimberly B., Sosman, Jeffrey A., Kefford, Richard F., Long, Georgina V., Nelson, Stanley F., Ribas, Antoni, Lo, Roger S.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530385/
https://ncbi.nlm.nih.gov/pubmed/22395615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1727
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