Melanoma whole exome sequencing identifies (V600E)B-RAF amplification-mediated acquired B-RAF inhibitor resistance

The development of acquired drug resistance hampers the long-term success of B-RAF inhibitor (B-RAFi) therapy for melanoma patients. Here we show (V600E)B-RAF copy number gain as a mechanism of acquired B-RAFi resistance in four out of twenty (20%) patients treated with B-RAFi. In cell lines, (V600E...

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Detaylı Bibliyografya
Asıl Yazarlar: Shi, Hubing, Moriceau, Gatien, Kong, Xiangju, Lee, Mi-Kyung, Lee, Hane, Koya, Richard C., Ng, Charles, Chodon, Thinle, Scolyer, Richard A., Dahlman, Kimberly B., Sosman, Jeffrey A., Kefford, Richard F., Long, Georgina V., Nelson, Stanley F., Ribas, Antoni, Lo, Roger S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2012
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530385/
https://ncbi.nlm.nih.gov/pubmed/22395615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1727
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