Mechanism of Loss of Kv11.1 K(+) Current in Mutant T421M-Kv11.1 Expressing Rat Ventricular Myocytes: Interaction of Trafficking and Gating

BACKGROUND: Type 2 long QT syndrome (LQT2) involves mutations in the human ether a-go-go-related gene (hERG or KCNH2). T421M, a S1 domain mutation in the Kv11.1 channel protein, was identified in a resuscitated patient. We assessed its biophysical, protein trafficking and pharmacological mechanisms...

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Autores principales: Balijepalli, Sadguna Y., Lim, Evi, Concannon, Sarah P., Chew, Chen L., Holzem, Kassandra E., Tester, David J., Ackerman, Michael J., Delisle, Brian P., Balijepalli, Ravi C., January, Craig T.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530382/
https://ncbi.nlm.nih.gov/pubmed/23136156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.112.118018
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