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High levels of IL-7 cause dysregulation of thymocyte development

IL-7 signaling is required for thymocyte development and its loss has a severe deleterious effect on thymus function. Thymocyte–stromal cell interactions and other mechanisms tightly regulate IL-7 expression. We show that disruption of that regulation by over-expression of IL-7 inhibits T-cell devel...

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Bibliografiske detaljer
Main Authors: El-Kassar, Nahed, Flomerfelt, Francis A., Choudhury, Baishakhi, Hugar, Lee A., Chua, Kevin S., Kapoor, Veena, Lucas, Philip J., Gress, Ronald E.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3530313/
https://ncbi.nlm.nih.gov/pubmed/22899673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/intimm/dxs067
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