Complement C1q Activates Canonical Wnt Signaling and Promotes Aging-Related Phenotypes

Wnt signaling plays critical roles in development of various organs and pathogenesis of many diseases, and augmented Wnt signaling has recently been implicated in mammalian aging and aging-related phenotypes. We here report that complement C1q activates canonical Wnt signaling and promotes aging-ass...

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Hauptverfasser: Naito, Atsuhiko T., Sumida, Tomokazu, Nomura, Seitaro, Liu, Mei-Lan, Higo, Tomoaki, Nakagawa, Akito, Okada, Katsuki, Sakai, Taku, Hashimoto, Akihito, Hara, Yurina, Shimizu, Ippei, Zhu, Weidong, Toko, Haruhiro, Katada, Akemi, Akazawa, Hiroshi, Oka, Toru, Lee, Jong-Kook, Minamino, Tohru, Nagai, Toshio, Walsh, Kenneth, Kikuchi, Akira, Matsumoto, Misako, Botto, Marina, Shiojima, Ichiro, Komuro, Issei
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529917/
https://ncbi.nlm.nih.gov/pubmed/22682250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.03.047
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