Phosphonopeptide antibacterial agents related to alafosfalin: design, synthesis, and structure-activity relationships.

Dipeptide variants of alafosfalin (L-alanyl-L-1-aminoethylphosphonic acid) with substantial differences in potency and antibacterial spectrum in vitro and in vivo have been synthesized. Certain dipeptides with alternatives to the L-alanyl residue had broader antibacterial spectra; activity against P...

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Bibliographic Details
Main Authors: Atherton, F R, Hall, M J, Hassall, C H, Holmes, S W, Lambert, R W, Lloyd, W J, Ringrose, P S
Format: Artigo
Language:Inglês
Published: 1980
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC352986/
https://ncbi.nlm.nih.gov/pubmed/7016027
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