A PLC-γ1-independent, RasGRP1-ERK dependent pathway drives lymphoproliferative disease in LAT-Y136F mutant mice

Mice expressing a germline mutation in the PLC-γ1 binding site of LAT (linker for activation of T cells) show progressive lymphoproliferation and ultimately die at 4–6 months of age. The hyper-activated T cells in these mice show defective TCR-induced calcium flux, but enhanced Ras/ERK activation th...

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Detalhes bibliográficos
Main Authors: Kortum, Robert L., Rouquette-Jazdanian, Alexandre K., Miyaji, Michihiko, Merrill, Robert K., Markegard, Evan, Pinski, John M., Wesselink, Amelia, Nath, Nandan N., Alexander, Clayton P., Li, Wenmei, Kedei, Noemi, Roose, Jeroen P., Blumberg, Peter M., Samelson, Lawrence E., Sommers, Connie L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529846/
https://ncbi.nlm.nih.gov/pubmed/23209318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201458
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