Impaired Thermogenesis and Adipose Tissue Development in Mice with Fat-Specific Disruption of Insulin and IGF-1 Signalling

Insulin and insulin-like growth factor 1 (IGF-1) play important roles in adipocyte differentiation, glucose tolerance and insulin sensitivity. Here, to assess how these pathways can compensate for each other, we created mice with a double tissue-specific knockout of insulin and IGF-1 receptors to el...

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Hlavní autoři: Boucher, Jeremie, Mori, Marcelo A., Lee, Kevin Y., Smyth, Graham, Liew, Chong Wee, Macotela, Yazmin, Rourk, Michael, Bluher, Matthias, Russell, Steven J., Kahn, C. Ronald
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529640/
https://ncbi.nlm.nih.gov/pubmed/22692545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1905
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