Role of microRNA Processing in Adipose Tissue in Stress Defense and Longevity

Excess adipose tissue is associated with metabolic disease and reduced lifespan, whereas caloric restriction decreases these risks. Here we show that as mice age, there is down-regulation of Dicer and miRNA processing in adipose tissue resulting in decreases of multiple miRNAs. A similar decline of...

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Bibliographic Details
Main Authors: Mori, Marcelo A., Raghavan, Prashant, Thomou, Thomas, Boucher, Jeremie, Robida-Stubbs, Stacey, Macotela, Yazmin, Russell, Steven J., Kirkland, James L., Blackwell, T. Keith, Kahn, C. Ronald
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3461823/
https://ncbi.nlm.nih.gov/pubmed/22958919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.07.017
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