Targeting Carcinoma-Associated Fibroblasts Within the Tumor Stroma With a Fibroblast Activation Protein-Activated Prodrug

BACKGROUND: Fibroblasts undergo a morphological transformation to a reactive phenotype in the tumor microenvironment characterized by the expression of proteins such as fibroblast activation protein (FAP), a post-prolyl endopeptidase with expression largely restricted to carcinoma-associated fibrobl...

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Hauptverfasser: Brennen, W. Nathaniel, Rosen, D. Marc, Wang, Hao, Isaacs, John T., Denmeade, Samuel R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529592/
https://ncbi.nlm.nih.gov/pubmed/22911669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djs336
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