Mitochondria Superoxide Anion Production Contributes to Geranylgeraniol-Induced Death in Leishmania amazonensis

Here we demonstrate the activity of geranylgeraniol, the major bioactive constituent from seeds of Bixa orellana, against Leishmania amazonensis. Geranylgeraniol was identified through (1)H and (13)C nuclear magnetic resonance imaging and DEPT. The compound inhibited the promastigote and intracellul...

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Hlavní autoři: Lopes, Milene Valéria, Desoti, Vânia Cristina, Caleare, Angelo de Oliveira, Ueda-Nakamura, Tânia, Silva, Sueli Oliveira, Nakamura, Celso Vataru
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi Publishing Corporation 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529489/
https://ncbi.nlm.nih.gov/pubmed/23304195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/298320
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