Mitochondria Superoxide Anion Production Contributes to Geranylgeraniol-Induced Death in Leishmania amazonensis

Here we demonstrate the activity of geranylgeraniol, the major bioactive constituent from seeds of Bixa orellana, against Leishmania amazonensis. Geranylgeraniol was identified through (1)H and (13)C nuclear magnetic resonance imaging and DEPT. The compound inhibited the promastigote and intracellul...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Lopes, Milene Valéria, Desoti, Vânia Cristina, Caleare, Angelo de Oliveira, Ueda-Nakamura, Tânia, Silva, Sueli Oliveira, Nakamura, Celso Vataru
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Hindawi Publishing Corporation 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529489/
https://ncbi.nlm.nih.gov/pubmed/23304195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/298320
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