Mitochondria Superoxide Anion Production Contributes to Geranylgeraniol-Induced Death in Leishmania amazonensis

Here we demonstrate the activity of geranylgeraniol, the major bioactive constituent from seeds of Bixa orellana, against Leishmania amazonensis. Geranylgeraniol was identified through (1)H and (13)C nuclear magnetic resonance imaging and DEPT. The compound inhibited the promastigote and intracellul...

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Detalhes bibliográficos
Main Authors: Lopes, Milene Valéria, Desoti, Vânia Cristina, Caleare, Angelo de Oliveira, Ueda-Nakamura, Tânia, Silva, Sueli Oliveira, Nakamura, Celso Vataru
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529489/
https://ncbi.nlm.nih.gov/pubmed/23304195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/298320
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