Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner

BACKGROUND: We have investigated a simple strategy for enhancing transgene expression specificity by leveraging genetic silencer elements. The approach serves to restrict transgene expression to a tissue of interest - the nervous system in the example provided here - thereby promoting specific/exclu...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Xie, Xiayang, Mathias, Jonathan R, Smith, Marie-Ange, Walker, Steven L, Teng, Yong, Distel, Martin, Köster, Reinhard W, Sirotkin, Howard I, Saxena, Meera T, Mumm, Jeff S
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Methodology Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529185/
https://ncbi.nlm.nih.gov/pubmed/23198762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-10-93
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker