Silencer-delimited transgenesis: NRSE/RE1 sequences promote neural-specific transgene expression in a NRSF/REST-dependent manner

BACKGROUND: We have investigated a simple strategy for enhancing transgene expression specificity by leveraging genetic silencer elements. The approach serves to restrict transgene expression to a tissue of interest - the nervous system in the example provided here - thereby promoting specific/exclu...

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Bibliographic Details
Main Authors: Xie, Xiayang, Mathias, Jonathan R, Smith, Marie-Ange, Walker, Steven L, Teng, Yong, Distel, Martin, Köster, Reinhard W, Sirotkin, Howard I, Saxena, Meera T, Mumm, Jeff S
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529185/
https://ncbi.nlm.nih.gov/pubmed/23198762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1741-7007-10-93
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