TRIM39 regulates cell cycle progression and DNA damage responses via stabilizing p21

The biological function of Tripartite Motif 39 (TRIM39) remains largely unknown. In this study, we report that TRIM39 regulates the steady-state levels of p21 and is a pivotal determinant of cell fate. Ablation of TRIM39 leads to destabilization of p21 and increased G1/S transition in unperturbed ce...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Zhang, Lei, Mei, Yang, Fu, Nai-yang, Guan, Li, Xie, Wei, Liu, Hui-hui, Yu, Chun-dong, Yin, Zhenyu, Yu, Victor C., You, Han
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2012
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529087/
https://ncbi.nlm.nih.gov/pubmed/23213251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214156110
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker