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Use of biotinylated plasmid DNA as a surrogate for HSV DNA to identify proteins that repress or activate viral gene expression

ICP0, a key herpes simplex virus regulatory protein, functions first in the nucleus and then in the cytoplasm. The duration of its nuclear sojourn in cells transfected with DNA and then infected is related to the quantity of transfected DNA. Furthermore, ICP0 transactivates both viral genes and gene...

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Bibliografske podrobnosti
Main Authors: Mallon, Stephen, Wakim, Bassam T., Roizman, Bernard
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3529035/
https://ncbi.nlm.nih.gov/pubmed/23223531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1218783109
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