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The Structural Basis of Functional Group Activation by Sulfotransferases in Complex Metabolic Pathways

Sulfated molecules with diverse functions are common in biology, but sulfonation as a method to activate a metabolite for chemical catalysis is rare. Catalytic activity was characterized and crystal structures were determined for two such “activating” sulfotransferases (STs) that sulfonate β-hydroxy...

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Detalhes bibliográficos
Main Authors: McCarthy, Jennifer Gehret, Eisman, Eli B., Kulkarni, Sarang, Gerwick, Lena, Gerwick, William H., Wipf, Peter, Sherman, David H., Smith, Janet L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528841/
https://ncbi.nlm.nih.gov/pubmed/22991895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300385m
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