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Loss of P2X7 Receptor Plasma Membrane Expression and Function in Pathogenic B220(+) Double-Negative T Lymphocytes of Autoimmune MRL/lpr Mice
Lupus is a chronic inflammatory autoimmune disease influenced by multiple genetic loci including Fas Ligand (FasL) and P2X7 receptor (P2X7R). The Fas/Fas Ligand apoptotic pathway is critical for immune homeostasis and peripheral tolerance. Normal effector T lymphocytes up-regulate the transmembrane...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3528777/ https://ncbi.nlm.nih.gov/pubmed/23284917 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052161 |
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