Loss of P2X7 Receptor Plasma Membrane Expression and Function in Pathogenic B220(+) Double-Negative T Lymphocytes of Autoimmune MRL/lpr Mice

Lupus is a chronic inflammatory autoimmune disease influenced by multiple genetic loci including Fas Ligand (FasL) and P2X7 receptor (P2X7R). The Fas/Fas Ligand apoptotic pathway is critical for immune homeostasis and peripheral tolerance. Normal effector T lymphocytes up-regulate the transmembrane...

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Detalhes bibliográficos
Main Authors: Le Gall, Sylvain M., Legrand, Julie, Benbijja, Mohcine, Safya, Hanaa, Benihoud, Karim, Kanellopoulos, Jean M., Bobé, Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528777/
https://ncbi.nlm.nih.gov/pubmed/23284917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0052161
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